Recruiting for Cocaine Study

Cocaine Research Study

Matrix is conducting a research study in search of a medication for cocaine addiction. Those seeking treatment for cocaine addiction may participate at no cost. The study will use either an investigational medication or placebo (sugar pills) plus outpatient counseling for those who are active cocaine users. Compensation may be provided for time and travel.

Participation Requirements

Must be a healthy adult, age 18 or older that is seeking treatment for cocaine addiction. For more information about participation, call 323-938-8184.

History of Matrix’s Involvement in Medication Trials for Cocaine Addiction

In the 1980’s, epidemic cocaine use in Los Angeles led the founders of Matrix to develop a new therapy approach to stimulant treatment, The Matrix Model. A lesser-known story is the years of attempts, many at Matrix, to find a medication to treat cocaine use disorder. For more than 30 years, researchers have assessed over 100 different medications for the treatment of this elusive disease. Many of these medications were tested in animal studies, with only about 10 examined through rigorous research. At Matrix, we have participated in several clinical trials over the past 20 years to find a treatment for addiction to cocaine. Among the medications tested at Matrix were desipramine, Ritanserin, SP 39166 (Schering-Plough Pharmaceuticals), vigabatrin, and nepicastat. Unfortunately, no medication to date is a candidate for FDA approval.

With so many medications failing to have a robust response in cocaine users, why continue searching? Thomas Edison’s light bulb comes to mind in this regard. Edison tested over 6,000 different materials, from bamboo to platinum, to find a filament that was long-lasting, yet cheap enough for the wider public. In this spirit, Matrix is continuing to participate in medication trials to find a treatment for cocaine use disorder and we are seeking patients with active cocaine use. Call 323-938-8184 for more information.

2017-06-08 Lorcaserin Cocaine Flyer

Research Investigators

Dan George, M.P.H., M.B.A.
Jeremy Martinez, M.D.
Tasnim Shamji, M.D.

This research study is funded by the National Institute on Drug Abuse.